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Symbol
Name
ID 		Ar
androgen receptor
MGI:88064
Phenotype annotations related to reproductive system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Clitoral hypertrophy
Fused labia majora
Labial hypoplasia
Hypospadias
Penoscrotal hypospadias
Perineal hypospadias
Micropenis
Bifid scrotum
Cryptorchidism
Bilateral cryptorchidism
Unilateral cryptorchidism
Testicular atrophy
Female external genitalia in individual with 46,XY karyotype
Ambiguous genitalia
Prostate cancer
Blind vagina
Urogenital sinus anomaly
Aplasia of the ovary
Endometrial carcinoma
Aplasia of the uterus
Primary amenorrhea
Azoospermia
Male sexual dysfunction
Decreased fertility
Male infertility
Germ cell neoplasia
Disease(s) Associated with AR
androgen insensitivity syndrome
cryptorchidism
endometrial cancer
hypospadias
Kennedy's disease
partial androgen insensitivity syndrome
prostate cancer

Mouse Phenotypes
reproductive system phenotype
abnormal sperm flagellum morphology
coiled sperm flagellum
hairpin sperm flagellum
kinked sperm flagellum
azoospermia
oligozoospermia
abnormal spermatid morphology
abnormal spermatocyte morphology
abnormal spermatogonia morphology
decreased male germ cell number
decreased germ cell number
increased male germ cell apoptosis
abnormal anogenital distance
short perineum
abnormal prostate gland morphology
abnormal prostate gland anterior lobe morphology
small prostate gland anterior lobe
decreased prostate gland anterior lobe weight
abnormal prostate gland epithelium morphology
decreased prostate gland ventral lobe weight
decreased prostate gland weight
small prostate gland
enlarged prostate gland ventral lobe
small prostate gland ventral lobe
absent prostate gland
abnormal seminal vesicle morphology
abnormal seminal vesicle epithelium morphology
abnormal seminal vesicle muscle layer morphology
decreased seminal vesicle weight
small seminal vesicle
absent seminal vesicle
decreased ovary weight
abnormal testis morphology
abnormal seminiferous tubule morphology
abnormal peritubular myoid cell morphology
abnormal Sertoli cell barrier morphology
abnormal Sertoli cell morphology
decreased Sertoli cell number
enlarged seminiferous tubules
small seminiferous tubules
seminiferous tubule degeneration
abnormal Leydig cell morphology
Leydig cell hypertrophy
abnormal adult Leydig cell differentiation
decreased Leydig cell number
increased Leydig cell number
decreased testis weight
enlarged testis
small testis
testicular atrophy
testis hypoplasia
cryptorchism
testis degeneration
increased testis tumor incidence
abnormal Sertoli cell barrier function
testis inflammation
abnormal penis morphology
abnormal foreskin morphology
small penis
abnormal female reproductive system morphology
decreased oviduct weight
decreased uterus weight
vagina atresia
blind vagina
abnormal gametogenesis
abnormal meiosis
arrest of male meiosis
abnormal sperm number
abnormal spermatogenesis
arrest of spermatogenesis
abnormal male reproductive system morphology
abnormal male genitalia morphology
abnormal external male genitalia morphology
abnormal scrotum morphology
absent scrotum
absent external male genitalia
abnormal epididymis morphology
abnormal caput epididymis morphology
abnormal cauda epididymis morphology
abnormal corpus epididymis morphology
abnormal epididymis epithelium morphology
epididymis epithelium degeneration
decreased epididymis weight
absent epididymis
absent vas deferens
abnormal reproductive system development
abnormal secondary sex determination
male pseudohermaphroditism
secondary sex reversal
abnormal reproductive system physiology
abnormal copulatory plug biosynthesis
female infertility
decreased litter size
male infertility
reduced male fertility
premature acrosome reaction
impaired fertilization
abnormal male reproductive system physiology
Availability Mouse Genotype
ArTfm-Jms/ArTfm-Jms !
Arem1Liuy/Y
ArTfm-Jms/Y
ArTfm/Y ! ! ! !
Artm1.1Chc/Y
Artm1.1Jdz/Y
Artm1.1Reb/Y
Artm1.1Verh/Y
Artm1Fcl/Y
Artm1Reb/Y
Artm1Verh/Y *
Artm1Jdz/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor  (conditional)
Artm1Jdz/Y
Tg(Abpa-cre)1Cmal/Tg(Abpa-cre)1Cmal  (conditional)
Amhr2tm3(cre)Bhr/Amhr2+
Artm1Chc/Y  (conditional)
Artm1Chc/Ar+
Tmem163Tg(ACTB-cre)2Mrt/0  (conditional)
Artm1Chc/Artm1.1Chc
Tmem163Tg(ACTB-cre)2Mrt/0  (conditional)
Artm2.1Reb/Ar+
Tg(Amh-cre)8815Reb/?  (conditional)
Artm2Ska/Y
Gli1tm3(cre/ERT2)Alj/Gli1+  (conditional)
Artm1Verh/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+  (conditional)
Artm1Chc/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+  (conditional)
Artm1Jdz/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Tg(Abpa-cre)1Cmal/0  (conditional)
Artm1Jdz/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+  (conditional)
Artm1Verh/Y
Rnase10tm1(cre)Hht/Rnase10+  (conditional)
Artm2Ska/Y
Shhtm2(cre/ERT2)Cjt/Shh+  (conditional)		 *
Artm1Chc/Y
Tmem163Tg(ACTB-cre)2Mrt/0  (conditional)
Artm1Chc/Y
Tg(Pbsn-cre)4Prb/0  (conditional)		 *
Artm1Chc/Y
Tg(Sycp1-cre)4Min/0  (conditional)		 *
Artm1Jdz/Y
Tg(Pbsn-cre)20Fwan/?  (conditional)		 *
Artm1Jdz/Y
Tg(Abpa-cre)1Cmal/0  (conditional)
Artm1Jdz/Y
Tg(CMV-cre)1Cgn/0  (conditional)
Artm1Reb/Y
Tg(Amh-cre)8815Reb/?  (conditional)
Artm1Ska/Y
Tg(CMV-cre)1Ipc/?  (conditional)
Artm2Ska/Y
Tg(KRT5-cre)1Tak/0  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory